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1

Designer gene networks: Towards fundamental cellular control

Hasty, Jeff, Isaacs, Farren, Dolnik, Milos, McMillen, David, Collins, J. J.

Journal:

Chaos An Interdisciplinary Journal of Nonlinear Science

Year:

2001

Language:

english

File:

PDF, 420 KB

english, 2001

2

Arrestin can act as a regulator of rhodopsin photochemistry

Martha E. Sommer, David L. Farrens

Journal:

Vision Research

Year:

2006

Language:

english

File:

PDF, 1.59 MB

english, 2006

3

Contributions of H G Khorana to understanding transmembrane signal transduction

Farrens, David L., Sakmar, Thomas P.

Journal:

Year:

2012

Language:

english

File:

PDF, 554 KB

english, 2012

4

Establishing hydroecological relationships to manage the impacts of groundwater abstraction

Bradley, David C., Streetly, Mike, Farren, Emma, Cadman, Daniel, Banham, Andrew

Journal:

Water and Environment Journal

Year:

2014

Language:

english

File:

PDF, 979 KB

english, 2014

5

10.1038/35066056

Hasty, Jeff, McMillen, David, Isaacs, Farren, Collins, James J.

Journal:

Nature Reviews Genetics

Year:

2001

Language:

english

File:

PDF, 1.42 MB

english, 2001

6

Coupling ligand structure to specific conformational switches in the β2-adrenoceptor

Yao, Xiaojie, Parnot, Charles, Deupi, Xavier, Ratnala, Venkata R P, Swaminath, Gayathri, Farrens, David, Kobilka, Brian

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 324 KB

english, 2006

7

SUBNANOSECOND SINGLE PHOTON TIMING MEASUREMENTS USING A PULSED DIODE-LASER

David L. Farrens, Pill-Soon Song

Journal:

Photochemistry and Photobiology

Year:

1991

Language:

english

File:

PDF, 384 KB

english, 1991

8

THE DISTANCE BETWEEN THE PHYTOCHROME CHROMOPHORE AND THE N-TERMINAL CHAIN DECREASES DURING PHOTOTRANSFORMATION. A NOVEL FLUORESCENCE ENERGY TRANSFER METHOD USING LABELED ANTIBODY FRAGMENTS

David L. Farrens, Marie-Michèle Cordonnier, Lee H. Pratt, Pill-Soon Song

Journal:

Photochemistry and Photobiology

Year:

1992

Language:

english

File:

PDF, 807 KB

english, 1992

9

Immunomonitoring in allograft recipients treated with a T cell depleting protocol and minimum immunosuppression

Carol Bentlejewski, Noriko Murase, Diana Metes, David Guaspari, Angie Farren, Pam McGregor, Adriana Zeevi

Journal:

Human Immunology

Year:

2004

Language:

english

File:

PDF, 21 KB

english, 2004

10

The Conformations of the Manganese Transport Regulator of Bacillus subtilis in its Metal-free State

Mark A. DeWitt, Joseph I. Kliegman, John D. Helmann, Richard G. Brennan, David L. Farrens, Arthur Glasfeld

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.16 MB

english, 2007

11

Monomeric Rhodopsin Is the Minimal Functional Unit Required for Arrestin Binding

Hisao Tsukamoto, Abhinav Sinha, Mark DeWitt, David L. Farrens

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

12

Phenotypic Consequences of Promoter-Mediated Transcriptional Noise

William J. Blake, Gábor Balázsi, Michael A. Kohanski, Farren J. Isaacs, Kevin F. Murphy, Yina Kuang, Charles R. Cantor, David R. Walt, James J. Collins

Journal:

Year:

2006

Language:

english

File:

PDF, 1.22 MB

english, 2006

13

Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms

Jay M. Janz, David L. Farrens

Journal:

Vision Research

Year:

2003

Language:

english

File:

PDF, 437 KB

english, 2003

14

Breast Cancer and Psychosocial Factors: Early Stressful Life Events, Social Support, and Well-Being

Karni Ginzburg, Margaret Wrensch, Terri Rice, Georgianna Farren, David Spiegel

Journal:

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

15

Mapping Proximity Within Proteins Using Fluorescence Spectroscopy: New Advances In Distance-dependent Tryptophan-induced Fluorescence Quenching

Mansoor, Steven E., DeWitt, Mark A., Farrens, David L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 41 KB

english, 2009

16

Microstructural Evolution and Mechanical Properties of Fusion Welds in an Iron-Copper-Based Multicomponent Steel

Farren, Jeffrey D., Hunter, Allen H., Dupont, John N., Seidman, David N., Robino, Charles V., Kozeschnik, Ernst

Journal:

Metallurgical and Materials Transactions A

Year:

2012

Language:

english

File:

PDF, 1.98 MB

english, 2012

17

An Atom-Probe Tomographic Study of Arc Welds in a Multi-Component High-Strength Low-Alloy Steel

Hunter, Allen H., Farren, Jeffrey D., DuPont, John N., Seidman, David N.

Journal:

Metallurgical and Materials Transactions A

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

18

Fluorescence spectroscopy of rhodopsins: Insights and approaches

Alexiev, Ulrike, Farrens, David L.

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2014

Language:

english

File:

PDF, 2.98 MB

english, 2014

19

Mapping Proximity within Proteins Using Fluorescence Spectroscopy. A Study of T4 Lysozyme Showing That Tryptophan Residues Quench Bimane Fluorescence †

Mansoor, Steven E., Mchaourab, Hassane S., Farrens, David L.

Journal:

Year:

2002

Language:

english

File:

PDF, 485 KB

english, 2002

20

The Membrane Proximal Region of the Cannabinoid Receptor CB 1 N-Terminus Can Allosterically Modulate Ligand Affinity

Fay, Jonathan F., Farrens, David L.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.79 MB

english, 2013

21

Single Proteoliposome Assay to Monitor Opsin and Cannabinoid Gpcr Homo-Oligomerization

Walsh, Samuel M., Mathiasen, Signe, Fay, Jonathan F., Farrens, David L., Stamou, Dimitrios

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 55 KB

english, 2014

22

Arrestin can Bind to a Single G-Protein Coupled Receptor

Tsukamoto, Hisao, Sinha, Abhinav, DeWitt, Mark, Farrens, David L.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 75 KB

english, 2010

23

Activating Mutations and Allosteric Modulators: Effects on GPCR Structure and Conformational Dynamics

Farrens, David L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 33 KB

english, 2012

24

Site-Directed Fluorescence Studies of Purified, Functional Cannabinoid Receptor Cb1: Agonist-Induced Conformational Changes in TM6 are Blocked by an Allosteric Modulator and Enhanced by a Novel CB1 Specific Antibody

Fay, Jonathan F., Farrens, David L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

25

Monitoring Conformational Changes During Agonist Release from a GPCR in Real Time: Transmembrane Helix 6 Resets as All-Trans Retinal is Released from Rhodopsin

Schafer, Chrisopher T., Janz, Jay M., Farrens, David L.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 43 KB

english, 2014

26

The Membrane Proximal Region of the Human Cannabinoid Receptor CB1 N-Terminus Allosterically Modulates Ligand Affinity

Fay, Jonathan F., Farrens, David L.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 42 KB

english, 2014

27

Interactions of Arrestin with Phosphorylated Opsin and the Role of All-trans Retinal

Sommer, Martha E., Farrens, David L., Hofmann, Klaus Peter, Heck, Martin

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 56 KB

english, 2009

28

What Programme for Government?

Basil McCrea, Seán Farren, Stephen Farry, Arlene Foster, Michelle Gildernew and David Ervine

Journal:

Year:

2006

Language:

english

File:

PDF, 1.21 MB

english, 2006

29

Surface-enhanced resonance Raman scattering (SERRS) spectroscopy applied to phytochrome and its model compounds. I. Biliverdin photoisomers

Holt, Randall E., Farrens, David L., Song, Pill Soon, Cotton, Therese M.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 904 KB

english, 1989

30

Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes

Mathiasen, Signe, Christensen, Sune M, Fung, Juan José, Rasmussen, Søren G F, Fay, Jonathan F, Jorgensen, Sune K, Veshaguri, Salome, Farrens, David L, Kiskowski, Maria, Kobilka, Brian, Stamou, Dimitri

Journal:

Year:

2014

Language:

english

File:

PDF, 749 KB

english, 2014

31

Time-resolved absorption studies of native etiolated oat phytochrome

Zhang, Chian Fan, Farrens, David L., Bjorling, Sofie C., Song, Pill Soon, Kliger, David S.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 1.57 MB

english, 1992

32

Characterization of Silkworm Chlorophyll Metabolites as an Active Photosensitizer for Photodynamic Therapy

Dai, Renke, Shoemaker, Richard, Farrens, David, Han, Man Jung, Kim, Choong Sup, Song, Pill-Soon

Journal:

Journal of Natural Products

Year:

1992

Language:

english

File:

PDF, 723 KB

english, 1992

33

Cysteine Residues in the Human Cannabinoid Receptor: Only C257 and C264 Are Required for a Functional Receptor, and Steric Bulk at C386 Impairs Antagonist SR141716A Binding †

Fay, Jonathan F., Dunham, Thomas D., Farrens, David L.

Journal:

Year:

2005

Language:

english

File:

PDF, 762 KB

english, 2005

34

Distance Mapping in Proteins Using Fluorescence Spectroscopy: The Tryptophan-Induced Quenching (TrIQ) Method

Mansoor, Steven E., DeWitt, Mark A., Farrens, David L.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.36 MB

english, 2010

35

Surface-enhanced resonance Raman scattering (SERRS) spectroscopy applied to phytochrome and its model compounds. 2. Phytochrome and phycocyanin chromophores

Farrens, David L., Holt, Randall E., Rospendowski, Bernard N., Song, Pill Soon, Cotton, Therese M.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 1.04 MB

english, 1989

36

Distance Mapping in Proteins Using Fluorescence Spectroscopy: Tyrosine, like Tryptophan, Quenches Bimane Fluorescence in a Distance-Dependent Manner

Jones Brunette, Amber M., Farrens, David L.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

37

Rhodopsin TM6 Can Interact with Two Separate and Distinct Sites on Arrestin: Evidence for Structural Plasticity and Multiple Docking Modes in Arrestin–Rhodopsin Binding

Sinha, Abhinav, Jones Brunette, Amber M., Fay, Jonathan F., Schafer, Christopher T., Farrens, David L.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.77 MB

english, 2014

38

Structure and Function in Rhodopsin. Cysteines 65 and 316 Are in Proximity in a Rhodopsin Mutant As Indicated by Disulfide Formation and Interactions between Attached Spin Labels †

Yang, Ke, Farrens, David L., Altenbach, Christian, Farahbakhsh, Zohreh T., Hubbell, Wayne L., Khorana, H. Gobind

Journal:

Year:

1996

Language:

english

File:

PDF, 522 KB

english, 1996

39

High-Throughput Protein Structural Analysis Using Site-Directed Fluorescence Labeling and the Bimane Derivative (2-Pyridyl)dithiobimane †

Mansoor, Steven E., Farrens, David L.

Journal:

Year:

2004

Language:

english

File:

PDF, 886 KB

english, 2004

40

Time-resolved circular dichroism of native oat phytochrome photointermediates

Bjorling, Sofie C., Zhang, Chian Fan, Farrens, David L., Song, Pill Soon, Kliger, David S.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 1.15 MB

english, 1992

41

Rhodopsin in Nanodiscs Has Native Membrane-like Photointermediates

Tsukamoto, Hisao, Szundi, Istvan, Lewis, James W., Farrens, David L., Kliger, David S.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

42

Determination of Protein Secondary Structure and Solvent Accessibility Using Site-Directed Fluorescence Labeling. Studies of T4 Lysozyme Using the Fluorescent Probe Monobromobimane †

Mansoor, Steven E., Mchaourab, Hassane S., Farrens, David L.

Journal:

Year:

1999

Language:

english

File:

PDF, 164 KB

english, 1999

43

Single-Cysteine Substitution Mutants at Amino Acid Positions 306−321 in Rhodopsin, the Sequence between the Cytoplasmic End of Helix VII and the Palmitoylation Sites: Sulfhydryl Reactivity and Transducin Activation Reveal a Tertiary Structure †,‡

Cai, Kewen, Klein-Seetharaman, Judith, Farrens, David, Zhang, Cheng, Altenbach, Christian, Hubbell, Wayne L., Khorana, H. Gobind

Journal:

Year:

1999

Language:

english

File:

PDF, 72 KB

english, 1999

44

Engineering a Functional Blue-Wavelength-Shifted Rhodopsin Mutant †

Janz, Jay M., Farrens, David L.

Journal:

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

45

Structure and Function in Rhodopsin. Single Cysteine Substitution Mutants in the Cytoplasmic Interhelical E−F Loop Region Show Position-Specific Effects in Transducin Activation †

Yang, Ke, Farrens, David L., Hubbell, Wayne L., Khorana, H. Gobind

Journal:

Year:

1996

Language:

english

File:

PDF, 613 KB

english, 1996

46

Structural Features and Light-Dependent Changes in the Cytoplasmic Interhelical E−F Loop Region of Rhodopsin: A Site-Directed Spin-Labeling Study †

Altenbach, Christian, Yang, Ke, Farrens, David L., Farahbakhsh, Zohreh T., Khorana, H. Gobind, Hubbell, Wayne L.

Journal:

Year:

1996

Language:

english

File:

PDF, 511 KB

english, 1996

47

What site-directed labeling studies tell us about the mechanism of rhodopsin activation and G-protein binding

Farrens, David L.

Journal:

Photochemical & Photobiological Sciences

Year:

2010

Language:

english

File:

PDF, 545 KB

english, 2010

48

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin

Schafer, Christopher T., Farrens, David L.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

49

Multi-component Cu-Strengthened Steel Welding Simulations: Atom Probe Tomography and Synchrotron X-ray Diffraction Analyses

Hunter, Allen H., Farren, Jeffrey D., DuPont, John N., Seidman, David N.

Journal:

Metallurgical and Materials Transactions A

Year:

2015

Language:

english

File:

PDF, 3.23 MB

english, 2015

50

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB 1

Fay, Jonathan F., Farrens, David L.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

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